VACCINE AGAINST BLUE TONGUE VIRUS AND IMMUNOGENIC COMPOSITIONS, METHODS OF THEIR APPLICATION AND PRODUCTION Russian patent published in 2012 - IPC A61K39/15 A61P31/12 

FIELD: veterinary.

SUBSTANCE: composition for the induction of the animal's immune response to Blue Tongue Virus (BTV) contains immunogenically efficient number of at least one strain of doubly inactivated Blue Tongue Virus and a biologically acceptable adjuvant; doubly inactivated Blue Tongue Virus is inactivated for the first time by the inactivating agent in concentration of approximately 10 mM and is inactivated for the second time by the inactivating agent in concentration of approximately 5 mM; the inactivating agent represents the binary ethylene inline (BEI); the applied adjuvant is chosen from the group consisting of one or several aluminum hydrates, saponins, SL-CD, Carbopol and SP-oil; one or several doses of the composition is injected to strengthen the animal's immune response to Blue Tongue Virus or prevent or reduce at least one symptom associated with that illness or to prevent or alleviate the Blue Tongue Virus outbreak; in purpose of production of inactivated integral Blue Tongue Virus it is treated by the inactivating agent, the proportion of the inactivating agent to BTV counts to 1:10; hereafter the received mixture is homogenated and decanted, after that BTV is treated by the inactivating agent for the second time in proportion to BTV - 1:20, hereafter the attained mixture is repeatedly homogenated and decanted and then neutralized for the adjustment of the final pH up to approximately 7.2.

EFFECT: group on inventions is an efficient means of protecting cud-chewing animals from infection caused by Blue Tongue Virus.

32 cl, 16 tbl, 5 ex