FIELD: chemistry.
SUBSTANCE: invention relates to a vaccine for vaccinating animals, recombinant BTV (bluetongue virus) vector, a method for preparation thereof, a method for vaccinating an animal against BTV, and a method for producing an immunogenic or protective response in an animal against BTV. Described vaccine comprises a recombinant BTV vector comprising a heterologous polynucleotide encoding a BTV polypeptide, wherein the recombinant BTV vector comprises a vector base derived from a genome selected from the group consisting of serotypes 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 and 26 BTV. Heterologous polynucleotide encodes an antigenic polypeptide from a BTV serotype that differs from the BTV serotype used as the vector backbone and is VP2.
EFFECT: inventions can be used to induce an immunogenic or protective response in animals against BTV.
25 cl, 18 dwg, 6 tbl, 4 ex
| Title | Year | Author | Number |
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|
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