NEW VACCINE COMPOSITIONS COMPRISING IMMUNOSTIMULATORY OLIGONUCLEOTIDES Russian patent published in 2017 - IPC A61K39/39 A61K39/08 A61K39/27 A61P31/00 

FIELD: medicine.

SUBSTANCE: vaccine composition comprises an antigen component and an adjuvant component, where the antigenic component comprises an EHV antigen (horse herpes virus), and the adjuvant component comprises an P-class immunostimulatory oligonucleotide and SP oil. At that, the SP oil comprises polyoxyethylene-polyoxypropylene block copolymer, squalane, and polyoxyethylene sorbitan monooleate obtained in a pharmaceutically acceptable diluent selected from the following: buffer, water, normal saline or growth media for cell culture, wherein the said SP oil is about 2-20 vol % / volume of vaccine composition.

EFFECT: P-class oligonucleotide and SP oil application in the inventive vaccine as a combination adjuvant provides a synergistic effect to enhance the immune response to a vaccine against horse the herpes virus.

10 cl, 8 tbl, 2 ex