PHENYL DERIVATIVES AND THEIR APPLICATION AS IMMUNOMODULATORS Russian patent published in 2012 - IPC C07D271/06 C07D271/107 A61K31/4245 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention refers to new phenyl derivatives with the formula (I) where # symbol indicates two carbon atoms of the phenyl ring bearing R¹, R² and R³; to each of the latter components the A group can be linked; and where A represents or where asterisks indicate the link through which the formula (I) is linked to the phenyl ring bearing R¹, R² and R³; R¹ represents hyndrogen or C_1-3-alkyl; R² represents C_2-5-alkyl or C_1-4-alkoxy group; R³ represents hydrogen, and in case when the A group is linked in the para-position in relation to the phenyl ring of the formula (I) bearing R¹, R² and R³, R³ can additionally represent the methyl group; R⁴ represents hydrogen; R⁵ represents C_1-3-alkyl; R⁶ represents a hydroxy group, di-(hydroxy-C_1-4-alkyl)-C_1-4-alkoxy group, 2,3-dihydroxypropoxy group, -OCH₂-CH(OH)-CH₂-NR⁶¹R⁶² or -OCH₂-CH(OH)-CH₂-NHCOR⁶⁴; R⁶¹ represents hydrogen; R⁶² represents hydrogen; R⁶⁴ represents hydroxymethyl; and R⁷ represents C_1-3-alkyl; and to its salt. The invention also refers to the pharmaceutical composition that is agonistic in relation to S1P1/EDG1 receptor on the basis of the mentioned compounds.

EFFECT: new compounds and the pharmaceutical composition based on them that may find their application in medicine as immunomodulating agents.

18 cl, 2 tbl, 28 ex