FIELD: chemistry.
SUBSTANCE: invention refers to new thiophene derivatives of formula (I) 
where A is represented by *-CO-CH2CH2-, *-CO-CH=CH, 
where the asterisks indicate the link through which the formula (I) thiophene group is bound; R1 is represented by C2-5alkyl; R2 is represented by hydrogen, methyl or ethyl; R3 is represented by hydrogen; R4 is represented by C1-4alkyl; R5 is represented by a hydroxy group, 2,3-di-hydroxypropoxygroup or -OCH2-CH(OH)-CH2-NHCOR52; R52 is represented by hydroxymethyl, and R6 is represented by C1-4alkyl; and to its salt. The invention also refers to the pharmaceutical composition that is agonistic in relation to S1P1/EDG1 receptor on the basis of the mentioned compounds.
EFFECT: new compounds and a composition based on them that may find their application in medicine as immunomodulating agents.
17 cl, 2 tbl, 44 ex
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