KINASE INHIBITORS Russian patent published in 2017 - IPC C07D471/04 A61K31/437 A61P11/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof which have an inhibitory activity against p38 MAP kinase. In formula (I), W is NH, Y is selected from the -O (CR³R⁴)_n- group, where n is 0, R¹ is (IIb) group , X₁ is -(CH)-, R⁹ is C₁-C₆alkyl, C₃-C₆cycloalkyl or phenyl optionally substituted with halogen atoms, R¹² is a hydrogen atom, A is a bivalent cycloalkylene radical having 5, 6 or 7 ring atoms, wherein the said cycloalkylene ring is attached to W and Y and fused to a phenyl ring, wherein such phenyl ring is optionally substituted with one or two R²⁷ groups, R²⁷ is selected from halogen, R² is a radical of formula (IVb) or (IVc) where R¹⁷ is selected from a single electron pair, hydrogen or aryl, where any such aryl may be optionally substituted by a C₁-C₆alkyl or C₃-C₇cycloalkyl; or R¹⁷th is a group of general formula (V) R²⁰ is selected from the group consisting of -CH₃ or -C₂H₅; R²¹ is -CH₃ or -C₂H₅; R¹⁸ is selected from the group consisting of a single electron pair, hydrogen, aryl, heteroaryl, -(C₁-₆alkyl), -(C₃-C₇cycloalkyl), -(C₃-C₇heterocycloalkyl), (C₅-C₇heterocycloalkyl)-(C₁-C₆alkyl) and (C₅-C₇heterocycloalkyl)-(C₃-C₆cycloalkyl) group, R¹⁹ Is selected from -CF₃, z¹, z², z³ and z⁴ are independently selected from the group consisting of C, N, O, -CH- and -NH- groups, in such combination that the resulting ring is an aromatic system, T is -CR²⁸=; R²⁸ is halogen; R²² is H or halogen. The invention also relates to a pharmaceutical composition comprising the said compounds, a method for treatment of diseases which benefit from p38 MAP kinase inhibition, and their application for manufacture of a medicament for treatment of such diseases.

EFFECT: increased efficiency of compounds application.

14 cl, 2 tbl, 35 ex