PHARMACEUTICAL COMPOSITION FOR INJECTIONS Russian patent published in 2012 - IPC A61K47/40 A61K47/48 A61K31/282 A61K33/24 A61K9/08 A61K9/19 A61P35/00 

Abstract RU 2443432 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: pharmaceutical composition for injections contains a mixture of platinum complex of formula II and at least one cyclodextrin and/or at least one cyclodextrin derivative selected from a group comprising alpha-, beta- and gamma-cyclodextrins and their alkylated derivatives in mass ratios within 1:0.1 to 10:1 respectively, and optionally at least one pharmaceutically acceptable excipient. The composition is presented in the form of an aqueous solution prepared by adding an aqueous medium to cyclodextrin or its derivative that is followed by adding the platinum complex of formula ;

or adding the aqueous medium to the mixed platinum complex of formula II and/or at least one cyclodextrin derivative; or adding cyclodextrin or its derivative to the suspension of the platinum complex of formula II in the aqueous medium.

EFFECT: preparing the inclusion complex in the aqueous medium is considerable facilitation of the method for producing the complex and preparing the injected pharmaceutical composition.

3 cl, 5 ex

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RU 2 443 432 C2

Authors

Frants Alesh

Sova Petr

Dates

2012-02-27Published

2007-06-20Filed