FIELD: medicine, pharmaceutics.
SUBSTANCE: pharmaceutical composition for injections contains a mixture of platinum complex of formula II and at least one cyclodextrin and/or at least one cyclodextrin derivative selected from a group comprising alpha-, beta- and gamma-cyclodextrins and their alkylated derivatives in mass ratios within 1:0.1 to 10:1 respectively, and optionally at least one pharmaceutically acceptable excipient. The composition is presented in the form of an aqueous solution prepared by adding an aqueous medium to cyclodextrin or its derivative that is followed by adding the platinum complex of formula ;
or adding the aqueous medium to the mixed platinum complex of formula II and/or at least one cyclodextrin derivative; or adding cyclodextrin or its derivative to the suspension of the platinum complex of formula II in the aqueous medium.
EFFECT: preparing the inclusion complex in the aqueous medium is considerable facilitation of the method for producing the complex and preparing the injected pharmaceutical composition.
3 cl, 5 ex
Authors
Dates
2012-02-27—Published
2007-06-20—Filed