FIELD: medicine.
SUBSTANCE: invention refers to conjugates of a polypeptide and an oligosaccharide or its pharmaceutically acceptable salt in which the polypeptide is conjugated to at least one oligosaccharide-spacer residues; the oligosaccharide represents a synthetic sulphated pentasaccharide residue and substantially shows affinity for antithrombine III, and the spacer shows a bond and is substantially a pharmacologically inactive flexible cross-link residue.
EFFECT: conjugates of the present invention have improved pharmacokinetic properties in comparison with appropriate unconjugated polypeptides.
13 cl, 24 dwg, 7 tbl, 28 ex
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