FIELD: pharmaceuticals.
SUBSTANCE: invention relates to insulin conjugates that contain an insulin molecule covalently bonded to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and where the saccharide is fucose.
EFFECT: insulin conjugates are characterised by a pharmacokinetic (PK) and / or pharmacodynamic (PD) profile which is sensitive to systemic concentrations of the saccharide, such as glucose or α-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
8 cl, 22 dwg, 1 tbl, 106 ex
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