FIELD: pharmaceuticals.
SUBSTANCE: invention relates to insulin conjugates that contain an insulin molecule covalently bonded to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and where the saccharide is fucose.
EFFECT: insulin conjugates are characterised by a pharmacokinetic (PK) and / or pharmacodynamic (PD) profile which is sensitive to systemic concentrations of the saccharide, such as glucose or α-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
8 cl, 22 dwg, 1 tbl, 106 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BIFUNCTION CYTOTOXIC AGENTS CONTAINING PHARMACOPHORE CTI | 2016 |
|
RU2682645C1 |
| ANTIBODY TO B7H3-EXATECAN ANALOGUE CONJUGATE AND ITS USE IN MEDICINE | 2019 |
|
RU2785664C2 |
| NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND USE THEREOF IN MEDICINAL PREPARATIONS | 2014 |
|
RU2694254C1 |
| PYRAZOLO-HETEROARYL DERIVATIVE, METHOD FOR ITS PREPARATION AND MEDICAL USE | 2017 |
|
RU2748833C2 |
| CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES | 2013 |
|
RU2649009C2 |
| FUNCTIONALISED DERIVATIVES OF MORPHOLINYLANTHRACYCLINE | 2015 |
|
RU2715902C2 |
| ANTIBODIES TO B7-H3 AND CONJUGATES OF ANTIBODY AND DRUG | 2017 |
|
RU2764651C2 |
| NOVEL 4-AMINO-N-HYDROXYBENZAMIDES AS HDAC INHIBITORS FOR TREATING CANCER | 2012 |
|
RU2591190C2 |
| CHEMICAL LINKERS AND CONJUGATES THEREOF | 2005 |
|
RU2402548C2 |
| SPLICEOSTATIN ANALOGS | 2013 |
|
RU2618523C2 |
