FIELD: organic chemistry, chemical technology, medicine, pharmacy.
SUBSTANCE: invention describes a novel pentasaccharide conjugate of the formula (I):
wherein R represents independently -SO- 3 or -CH3; insert represents a flexible insert of length 13-25 atoms. Charge of a pentasaccharide residue is equilibrated with positively charged counterions and the total amount of sulfate groups in a pentasaccharide residue is 4, 5 or 6. Also, invention relates to a method of its preparing and pharmaceutical composition based on thereof and used in treatment of diseases mediated or associated with thrombin.
EFFECT: improved preparing method, valuable medicinal properties of conjugate.
9 cl, 2 ex
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