FIELD: biotechnology; medicine.
SUBSTANCE: invention claimed is a derivative of a polypeptide acylated at a lysine amino acid residue selected from the group consisting of insulin, glucagon-like peptide-1, parathyroid hormone, and combinations thereof. Experimental results show that said polypeptide derivative has a significantly increased half-life while retaining its biological activity.
EFFECT: invention can be used in treatment of osteoporosis, diabetes and hyperglycemia.
10 cl, 3 tbl, 10 ex
