FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to a sublingual tablet and a method for preparing it. The sublingual tablet contains an opioid 20 mg/tablet applicable for sublingual application, a directly compressible diluent in the form of an inert core presenting considerably spherical granules containing sucrose and starch. The inert core is covered with at least one active layer containing at least 5 wt % of the inert core of said opioid. A method for preparing the sublingual low-dose opioid tablet involves a stage of producing microgranules by spraying a solution, a suspension or a colloidal dispersion containing said opioid on a surface of the inert core, and compressing the prepared microgranules. The sublingual tablets under the invention have disintegration time making less than 15 min., and fragility making less than 1%.
EFFECT: fast opioid release promotes immediate absorption of the latter in a buccal cavity and fast pain management.
22 cl, 1 dwg, 5 tbl, 3 ex
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