SOLID DOSAGE FORMS OF NARCOTIC DRUGS OF ENHANCED ABSORPTION IN TRANSBUCCAL ADMINISTRATION Russian patent published in 2011 - IPC A61K31/4468 A61K47/18 A61K9/20 A61P29/00

Abstract RU 2408373 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: pharmaceutical compositions in the form of a mouth dissolving tablet are described. The composition contains an effective amount of a narcotic active material representing fentanyl, and arginine being a pharmaceutically acceptable amine. The molar ratio of arginine to said active material is at least approximately 5:1. In the preferential version of the invention, tablet disintegration time in vivo is 5 to 25 minutes.

EFFECT: invention provides enhanced fentanyl absorption in transbuccal administration of the tablets.

7 cl, 2 tbl, 3 ex

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RU 2 408 373 C2

Authors

Stroppolo Federiko

Ardalan Shakhbaz

Dates

2011-01-10—Published

2006-07-21—Filed