METHOD OF LABORATORY EVALUATION OF PROPENSITY FOR HIGH BREAST DENSITY IN POSTMENOPAUSAL WOMEN Russian patent published in 2012 - IPC A61B10/00 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly oncology, endocrinology and X-ray diagnostics. For the purpose of evaluation of the propensity for high breast density in postmenopausal women, blood is examined for five parameters: reactive insulinemia, relation of generation of active oxygen forms in mononuclears to reactive insulinemia, glyoxalase activity in mononuclears on an empty stomach, relation of glyoxalase activity at 120-min oral glucose tolerance test to glucose activity on an empty stomach and an amount of blood circulating stem cells CD90+. Each parameters is appraised by points. If score is ≥ 4, the propensity for high breast density is concluded.

EFFECT: method enables optimising an approach to describing a group of postmenopausal women prone for high mammography breast density based on evaluation of laboratory parameters showing potential mechanisms of such high mammography breast density associated with weakened endocrine and intensified progenotoxic glucose effect and lower blood content of stem cell CD90+ marker showing according to some reports a suppressor function of a malignant process.