COMPOSITIONS AND METHODS OF TREATING KIT- AND PDGFRα-MEDIATED DISEASES Russian patent published in 2024 - IPC C07D487/04 A61K31/53 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, where A is

R₁ is selected from hydrogen and methyl; R₂ is selected from hydrogen and methyl or R₁ and R₂ together form cyclopropyl; R₃ is selected from hydrogen and methyl; R₄ is selected from hydrogen and methyl or R₃ and R₄ together form cyclopropyl; R₅ is selected from hydrogen and methyl; R₆ is selected from hydrogen and methyl, or R₅ and R₆ together form cyclopropyl, or one of R₂ or R₄ together with R₆ form cyclobutyl; R₇ is hydrogen, or one of R₂, R₄, or R₆ together with R₇ form a ring selected from oxetane, tetrahydrofuran and tetrahydropyran, wherein said tetrahydrofuran or tetrahydropyran optionally contains a hydroxyl as a substitute; m is 0 or 1; and n is 0 or 1. Invention also relates to a pharmaceutical composition based on said compound.

EFFECT: obtaining a new compound and a pharmaceutical composition based thereon, which can find application in medicine for treating KIT- and PDGFRα-mediated diseases, particularly gastrointestinal stromal tumors and systemic mastocytosis.

20 cl, 7 tbl, 22 ex