Show metadata Hide metadata

(19)

(11)

2 446 164

(13)

(51)

IPC

C07D261/20(2006-01-01)

(21) (22)

Application

2010120060/04, 2010-05-19

(24)

Start date

2010-05-19

(22)

Actual filing date

2010-05-19

(45)

Published

2012-03-27

(72)

Inventor

Filimonov Sergej IvanovichChirkova Zhanna VjacheslavovnaAbramov Igor' Gennad'EvichEvstifeeva Ljudmila Vladimirovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Tekhnicheskij Universitet" Vpo

METHOD OF PRODUCING 3-SUBSTITUTED 1,2-BENZISOXAZOLE-5,6-DICARBONITRILES Russian patent published in 2012 - IPC C07D261/20

Abstract RU 2446164 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 3-substituted 1,2-benzisoxazole-5,6-dicarbonitriles of general formula

(I), where a R=4-Me-C₆H₄; b R=4-MeO-C₆H₄; c R=2-thienyl. The method is realised by reacting 4-bromo-5-nitrophthalonitrile and sodium salts of 2,4-dioxobutanoic acid derivatives at temperature 55…70°C and molar ratio 1:2, respectively, for 18-24 hours in dimethyl formamide solution. The reaction mass is then diluted with ten-fold excess water at temperature T=0…25°C, the obtained resinous residue is extracted with methylene chloride, thoroughly washed with water and chromatographed on silica gel. The eluent (solvent) is evaporated and the precipitate is filtered off and recrystallised from alcohol.

EFFECT: method of obtaining novel 3-substituted 1,2-benzisoxazole-5,6-dicarbonitriles.

1 dwg, 3 ex

Similar patents RU2446164C2

Title	Year	Author	Number
METHOD OF PRODUCING ETHERS OF SUBSTITUTED 5,6-DICYANOBENZOFURAN-2-CARBOXYLIC ACIDS	2010	Filimonov Sergej Ivanovich Chirkova Zhanna Vjacheslavovna Abramov Igor' Gennad'Evich Evstifeeva Ljudmila Vladimirovna	RU2446143C2
METHOD OF PRODUCING SUBSTITUTED BENZOFURAN-5,6-DICARBONITRILES	2009	Filimonov Sergej Ivanovich Chirkova Zhanna Vjacheslavovna Abramov Igor' Gennad'Evich Danilova Angelina Sergeevna Makovkina Ol'Ga Vladimirovna	RU2429235C2
METHOD OF PRODUCING SUBSTITUTED 4-HYDROXY-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-6,7-DICARBONITRILES BASED ON 4-BROMO-5-NITROPHTHALONITRILE	2009	Filimonov Sergej Ivanovich Chirkova Zhanna Vjacheslavovna Abramov Igor' Gennad'Evich	RU2425047C9
METHOD OF PRODUCING 3-SUBSTITUTED 2-AMINO-1-HYDROXY-5,6-DICYANOINDOLES BASED ON 4-BROMO-5-NITROPHTHALONITRILE	2009	Filimonov Sergej Ivanovich Chirkova Zhanna Vjacheslavovna Abramov Igor' Gennad'Evich Sharunov Vladimir Sergeevich	RU2425031C1
METHOD OF PRODUCING SUBSTITUTED 4-[CYANO(PHENYL)METHYL]-5-NITROPHTHALONITRILES BASED ON 4-BROMO-5-NITROPHTHALONITRILE	2009	Filimonov Sergej Ivanovich Chirkova Zhanna Vjacheslavovna Abramov Igor' Gennad'Evich Sharunov Vladimir Sergeevich Dobrokhotov Oleg Vladimirovich	RU2428413C1
METHOD OF PRODUCING SUBSTITUTED 4-NITRO-5-(2-OXOETHYL)PHTHALONITRILES	2010	Filimonov Sergej Ivanovich Chirkova Zhanna Vjacheslavovna Abramov Igor' Gennad'Evich Evstifeeva Ljudmila Vladimirovna	RU2443681C2
METHOD OF PRODUCING 1-HYDROXY-3-R-INDOLE-5,6-DICARBONITRILES	2013	Chirkova Zhanna Vjacheslavovna Filimonov Sergej Ivanovich Abramov Igor' Gennad'Evich Kabanova Marija Valer'Evna	RU2534988C1
METHOD OF PRODUCING SUBSTITUTED 7,8-DICYANOPYRIMIDO[2,1-b][1,3]BENZOTHIAZOLES	2012	Chirkova Zhanna Vjacheslavovna Filimonov Sergej Ivanovich Abramov Igor' Gennad'Evich Tukhvatshin Rinat Shakir'Janovich	RU2508292C1
METHOD OF PRODUCING 2,3-DISUBSTITUTED 1-HYDROXY-1H-INDOLE-5,6-DICARBONITRILES	2017	Chirkova Zhanna Vyacheslavovna Filimonov Sergej Ivanovich Abramov Igor Gennadevich Vasonov Evgenij Alekseevich	RU2641006C1
METHOD OF OBTAINING DERIVATIVES OF DIBENZOCYCLOHEPTENE, RACEMATE OR OPTICALLY ACTIVE SALTS THEREOF	0	Lyusen Nedelek Daniel Freshke	SU651704A3

RU 2 446 164 C2

Authors

Filimonov Sergej Ivanovich

Chirkova Zhanna Vjacheslavovna

Abramov Igor' Gennad'Evich

Evstifeeva Ljudmila Vladimirovna

Dates

2012-03-27—Published

2010-05-19—Filed