FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing substituted 4-nitro-5-(2-oxoethyl)phthalonitriles of formula 
, where R=4-Me-C6H4, 4-MeO-C6H4, 2-thienyl, which can be used as precursors for producing biologically active substances and synthesis of phthalocyanines. The method involves use of 4-bromo-5-nitrophthalonitrile and sodium salts of 2,4-dioxobutanoic acid derivatives as initial reagents for synthesis of substituted 4-nitro-5-(2-oxoethyl)phthalonitriles. Reaction of said reagents takes place at temperature 18…35°C and molar ratio 1:2, respectively, for 18-24 hours in dimethylformamide solution. The reaction mass is then diluted with ten-fold excess 5% hydrochloric acid solution. The crystalline precipitate is filtered off and recrystallised from alcohol.
EFFECT: method enables to obtain substituted compounds with good output.
1 tbl, 3 ex
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| METHOD OF PRODUCING 4-[2-CHLORO-1-FORMYL-2-R-VINYL]-5-NITROPHTHALONITRILES | 2013 |
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