METHOD OF PRODUCING SUBSTITUTED BENZOFURAN-5,6-DICARBONITRILES Russian patent published in 2011 - IPC C07D307/84 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing novel substituted benzofuran-5,6-dicarbonitriles of general formula 1:

, where 1. R=R₁=CH₃; 2. R=OC₂H₅, R₁=CH₃; 3. R=OC₂H₅, R₁=C₆H₅; 4. R=4-C₆H₄-CH₃, R₁=CH₃; 5. R=4-C₆H₄-OCH₃, R₁=CH₃; 6. R=4-C₆H₄-Cl, R₁=CH₃; 7. R=2-Tiof, R₁=CH₃; involving reaction of 4-bromo-5-nitrophthalonitrile with sodium salts of substitured 1,3-dicarbonyl compounds (sodium salt of substituted 1,3-diketones) at temperature 30-40°C for 2-12 hours and molar ratio 4-bromo-5-nitrophthalonitrile: sodium salt of substituted 1,3-diketone=1:2, followed by pouring the reaction mass into 10 ml of cold 1% hydrochloric acid solution. The precipitated resinous residue is extracted with methylene chloride, thoroughly washed with water and chromatographed on silica gel and the eluent (solvent) is evaporated. Said compounds can be used as semi-products in synthesis of fluorescent and biologically active substances.

EFFECT: improved method for synthesis of benzofuran-5,6-dicarbonitriles.

1 cl, 1 tbl, 7 ex