METHOD OF PRODUCING 2,3-DISUBSTITUTED 1-HYDROXY-1H-INDOLE-5,6-DICARBONITRILES Russian patent published in 2018 - IPC C07D209/42 C07D209/12 C07D333/10 

FIELD: chemistry.

SUBSTANCE: invention relates to the method of prosucing novel 2,3-disubstituted 1-hydroxy-1H-indole-5,6-dicarbonitriles in which R¹=C₆H₅, or 4-CH₃C₆H₄, or 4-OCH₃C₆H₄, or 2-thienyl, R²=CH₃, or C₂H₅, or C₃H₇, which can be used as precursors for the synthesis of biologically active substances, drugs, phthalocyanines, hexazocyclones. The method of producing 2,3-disubstituted 1-hydroxy-1H-indole-5,6-dicarbonitriles involves two steps. At the first step, 2-substituted 1-hydroxy-1 h-indole-5,6-dicarbonitriles interact with aliphatic acid anhydrides of carboxylic acids (acetic, propionic, oil anhydride) in the presence of boron-fluoride-three etherate (BF₃Et₂O). At the second step, obtained corresponding 3-acetamidine 2-aryl(heteryl)-1H-indole-5,6-dicarbonitriles interact with potassium carbonate in the environment of isopropyl alcohol, followed by acidification and production of the desired 2,3-disubstituted 1-hydroxy-1H-indole-5,6-dicarbonitriles. .

EFFECT: new compound is produced that has high energy characteristics.

8 ex