C-MET/HGFR INHIBITOR POLYMORPHS Russian patent published in 2012 - IPC C07D487/04 A61K31/519 A61P35/00 

Abstract RU 2446168 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to polymorph of 2-[4-(3-quinolin-6-ylmethyl-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)pyrazol-1-yl]ethanol, particularly to a new crystalline phosphate salt of 2-[4-(3-quinolin-6-ylmethyl-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)pyrazol-1-yl]ethanol.

EFFECT: preparing the pharmaceutical composition and using the new salt in treating cell growth abnormalities, such as cancer in mammals.

10 cl, 10 dwg, 6 tbl, 5 ex

Similar patents RU2446168C2

Title Year Author Number
C-ANILINOQUINAZOLINE COMPOUNDS AND THEIR USE IN CANCER TREATMENT 2018
  • Grecu Tudor
  • Kettle Jason Grant
  • Packer Martin John
  • Pearson Stuart Eric
  • Smith James Michael
RU2769694C2
CRYSTALLINE TOSYLATE SALT (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8-9-DIHYDRO-2H-PYRIDO[4,3,2-de]PHTHALAZIN-3(7H)-ONE 2011
  • Van Bin
  • Chu Deniel
  • Lyu Yunbo
  • Pen Shichun
RU2598606C2
TOSYLATE SALT OF TRANS-N-ISOBUTYL-3-FLUORO-3-[3-FLUORO-4-(PYRROLIDIN-1-YLMETHYL)PHENYL]CYCLOBUTANE CARBOXAMIDE 2008
  • Vager Trevis T.
  • Batler Todd Uill'Jam
RU2451016C2
NEW DERIVATIVES OF IMIDAZO [4,5-C] QUINOLINES AND IMIDAZO [4,5-C] [1,5] NAPHTHYRIDINES AS LRRK2 INHIBITORS 2016
  • Galatsis Paul
  • Henderson Jaclyn Louise
  • Kormos Bethany Lyn
  • Kurumbail Ravi G.
  • Reese Matthew Richard
  • Stepan Antonia Friederike
  • Verhoest Patrick Robert
  • Wager Travis T.
  • Pettersson Martin Youngjin
  • Garnsey Michelle Renee
RU2722149C1
NONHYGROSCOPIC CRYSTALLINE 5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[(2S)-2-HYDROXY-3-MORPHOLIN-4-YLPROPYL]-2,4-DIMETHYL-1H-PYRROL-3-CARBOXAMIDE MALEATE SALT, PHARMACEUTICAL COMPOSITION AND METHOD FOR CANCER TREATMENT 2004
  • Blasko Andrej
  • Tszin' Tsinvu
  • Lu Tsjun'
  • Morejdzhis Majkl Ehntoni
  • Song Dong
  • Vondervell Brenda S'Ju
RU2319702C2
NOVEL CRYSTALLINE FORM OF TRIAZOLO(4,5-d)PYRIMIDINE 2005
  • Bolin Martin
  • Kosgrouv Stiv
  • Lassen Bo
RU2418802C2
NEW TRIAZOLOPYRASINE DERIVATIVES AND THEIR APPLICATION 2013
  • Dzhun Khee Dzhun
  • Kha Dzhe Du
  • Cho Sun Yun
  • Kim Kheun Re
  • Lee Kvan Kho
  • Lee Chkhon Ok
  • Chkhoi San Un
  • Park Chkhi Khoon
RU2643361C2
NEW CRYSTAL AND AMORPHOUS FORM OF TRYAZOL[4,5-d] PYRIMIDINE 2001
  • Bolin Martin
  • Kosgrouv Stiv
  • Lassen Bo
RU2325391C2
NEW IMIDAZO[4,5-c]QUINOLINE DERIVATIVES AS LRRK2 INHIBITORS 2018
  • Brodney Michael Aaron
  • Chappie Thomas Allen
  • Chen Jinshan Michael
  • Coe Jotham Wadsworth
  • Coffman Karen Jean
  • Galatsis Paul
  • Garnsey Michelle Renee
  • Helal Christopher John
  • Henderson Jaclyn Louise
  • Kormos Bethany Lyn
  • Kurumbail Ravi G.
  • Martinez-Alsina Luis Angel
  • Pettersson Martin Youngjin
  • Reese Matthew Richard
  • Rose Colin Richard
  • Stepan Antonia Friederike
  • Verhoest Patrick Robert
  • Wager Travis T.
  • Warmus Joseph Scott
  • Zhang Yuan
RU2773516C2
AMINOPYRAZINE COMPOUNDS WITH THE A2A ANTAGONIST PROPERTIES 2015
  • Yu, Younong
  • Lim, Yeon-Hee
  • Deng, Qiaolin
  • Kim, David
  • Zhou, Gang
  • Wang, Hongwu
  • Stamford, Andrew
  • Berlin, Michael
  • Wu, Heping
  • Ali, Amjad
  • Ting, Pauline
  • Kuang, Rongze
RU2727805C2

RU 2 446 168 C2

Authors

Kollman Bendzhamin Mikakh

Tsuj Tszinzhun Dzhin

Dates

2012-03-27Published

2008-11-18Filed