FIELD: chemistry.
SUBSTANCE: invention relates to a tosylate salt of trans-N-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane carboxamide of formula (1):
, which exhibits histamine-3 (H3) receptor antagonist activity.
EFFECT: possibility of use in a method of treating several diseases.
12 cl, 1 tbl, 6 dwg, 1 ex
| Title |
Year |
Author |
Number |
| TOSYLATE SALT OF THERAPEUTIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF |
2008 |
- Uehjger Trehvis T.
- Batler Todd Uill'Jam
|
RU2430099C2 |
| HYDROCHLORIDE SALT OF 5-[3-(3-HYDROXYPHENOXY)AZETIDIN-1-YL]-5-METHYL-2,2-DIPHENYLHEXANAMIDE |
2008 |
- Glossop Pol Alan
- Dzhejms Kim
|
RU2422439C2 |
| SUBSTITUTED N-PHENYLPYRROLIDINYL METHYLPYRROLIDINE AMIDES AND THERAPEUTIC USE THEREOF AS MODULATORS OF HISTAMINE H3 RECEPTOR |
2008 |
- Chekhtizkij Verngard
- Gao Chzhunli
- Kherst Uill'Jam Dzh.
- Shvink Lotar
- Shtengelin Zigfrid
|
RU2477721C2 |
| C-MET/HGFR INHIBITOR POLYMORPHS |
2008 |
- Kollman Bendzhamin Mikakh
- Tsuj Tszinzhun Dzhin
|
RU2446168C2 |
| CRYSTALLINE TOSYLATE SALT (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8-9-DIHYDRO-2H-PYRIDO[4,3,2-de]PHTHALAZIN-3(7H)-ONE |
2011 |
- Van Bin
- Chu Deniel
- Lyu Yunbo
- Pen Shichun
|
RU2598606C2 |
| POLYMORPHOUS AND AMORPHOUS FORMS OF {2-FLUORINE-5-[3-((E)-2-PYRIDINE-2-ILVINYL)-1N-INDAZOLE-6-ILAMINE]PHENYL}AMIDE 2, 5-DIMETHYL-2N-PYRAZOLE-3-CARBONIC ACID |
2005 |
- E Tsjan'
- Zuk Skott Ehdvard
- Oullet Majkl Allen
- Khettinger Donald Nikolas
- Srirangam Dzhajaram Kasturi
- Kanija Robert Stiven
- Saeed Nabil' Lauze
- Uajtlin Mehtt'Ju Dehvid
- Mitchell Mark Brajan
|
RU2324692C1 |
| NONHYGROSCOPIC CRYSTALLINE 5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[(2S)-2-HYDROXY-3-MORPHOLIN-4-YLPROPYL]-2,4-DIMETHYL-1H-PYRROL-3-CARBOXAMIDE MALEATE SALT, PHARMACEUTICAL COMPOSITION AND METHOD FOR CANCER TREATMENT |
2004 |
- Blasko Andrej
- Tszin' Tsinvu
- Lu Tsjun'
- Morejdzhis Majkl Ehntoni
- Song Dong
- Vondervell Brenda S'Ju
|
RU2319702C2 |
| NOVEL FUMARATE SALTS OF H3 HISTAMINE RECEPTOR ANTAGONISTS |
2010 |
- Landzhevin Beverli S.
- Farr Robert Allan
- Shakh Dinubkhaj Kh.
- Sherer Daniehl'
|
RU2537847C2 |
| CRYSTALLINE FORMS OF (R)-5-[3-CHLORO-4-(2, 3-DIHYDROXYPROPOXY)BEZ[Z]ILIDEN]-2-([Z]-PROPYLIMINO)-3-o-TOLYLTHIAZOLIDIN-4-ONE |
2009 |
- Nikolas Bonkhem
- Shtefan Bukhmann
- Aleks Ehberlin
- Kristof Imboden
- Markus Fon-Raumer
|
RU2519548C2 |
| NOVEL SALT AND MEDICAL APPLICATION |
2012 |
- Ali Zakhid
- Batcher Kennet Dzhon
- Batt Richard Filip
- Felsted Stefan Dzhon
- Glett Sofi
- Makkernan Rat Mitchell
- Pejnser Mejninder
|
RU2609011C2 |
