METHOD OF PRODUCING HYBRID TWO-PHASE SYSTEM OF DELIVERY OF POORLY SOLUBLE AND INSOLUBLE IN WATER BIOLOGICALLY ACTIVE SUBSTANCES WITH CONTROLLED RELEASE KINETIC Russian patent published in 2017 - IPC A61K9/16 A61K31/00 A61K47/30 B82B1/00 B82Y5/00 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to pharmaceutical industry, namely, to system of delivery of poorly soluble and insoluble biologically active substances (BAS) with controlled release kinetics, which is spherical nanoparticles containing hydrophobic core formed of biocompatible and biodegradable hydrophobic polymers, such as polyhydroxybutyrate, polylactide, polyglycolide, polydioxanone, poly-ε-caprolactone, polyhydroxyvalerate, copolymer of lactic and glycolic acids, in which there is a partially soluble or insoluble in water BAS; wherein hydrophobic core is surrounded with hydrophilic fragments of amphiphilic polymers consisting of one fragment of water-soluble carbon chain polymer with molecular weight M_n=1,000-30,000 Da and one end hydrophobic group, including one aliphatic radical with carbon atoms number in carbon chain 9÷20, as well as to method of producing such system of delivery.

EFFECT: group of inventions provides higher water compatibility of poorly soluble and insoluble BAS, increased stability of medicinal substances and possibility of controlling release rate of BAS.

6 cl, 7 ex, 6 tbl, 15 dwg