Show metadata Hide metadata

(19)

(11)

2 448 087

(13)

(51)

IPC

C07C311/48(2006-01-01)

C07C317/14(2006-01-01)

C07C323/67(2006-01-01)

C07D207/36(2006-01-01)

C07D215/28(2006-01-01)

C07D215/36(2006-01-01)

C07D233/84(2006-01-01)

A61K31/18(2006-01-01)

A61P9/04(2006-01-01)

(21) (22)

Application

2008141151/04, 2007-03-16

(24)

Start date

2007-03-16

(22)

Actual filing date

2007-03-16

(45)

Published

2012-04-20

(72)

Inventor

Toskano Dzhon P.Brukfild Frederik ArturKoehn Ehndrju D.Kortni Stefen MartinFrost Liza MariKalish Vinsent Dzhejkob

(73)

Holder

Dzhons Khopkins Juniversiti Skul Of MedsinKardioksil Farmas'Jutikalz, Ink.

N-HYDROXYLSULPHONAMIDE DERIVATIVES AS NOVEL PHYSIOLOGICALLY USEFUL NITROXYL DONORS Russian patent published in 2012 - IPC C07C311/48 C07C317/14 C07C323/67 C07D207/36 C07D215/28 C07D215/36 C07D233/84 A61K31/18 A61P9/04

Abstract RU 2448087 C2

FIELD: chemistry.

SUBSTANCE: invention relates to N-hydroxysulphonamide derivatives of formula where: R¹ denotes H; R² denotes H; R³, R⁴, R⁵, R⁶ and R⁷ are independently selected from a group consisting of H, halogen, perfluoromethyl and alkylsulphonyl, which release nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases and conditions which are responsive to nitroxyl therapy, including heart failure.

EFFECT: novel N-hydroxysulphonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of release of HNO changed by varying the nature and position of functional groups in N-hydroxysulphonamide derivatives.

38 cl, 5 tbl, 8 ex

Similar patents RU2448087C2

Title	Year	Author	Number
N-HYDROXILSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS	2007	Toskano Dzhon P. Brukfild Frederik Artur Koen Endryu D. Kortni Stefen Martin Frost Liza Mari Kalish Vinsent Dzhejkob	RU2616292C2
N-HYDROXYLSULPHONAMIDE DERIVATIVES AS NOVEL PHYSIOLOGICALLY USEFUL NITROXYL DONORS	2008	Toskano Dzhon P. Brukfild Frederik Artur Koehn Ehndrju D. Kortni Stefen Martin Frost Liza Mari Kalish Vinsent Dzhejkob	RU2485097C2
THERAPEUTIC COMPOUNDS AND COMPOSITIONS	2015	Chrusciel Robert A. Gadwood Robert C. Hayward Neil J. Melnick Michael J. Navia Manuel Poel Toni J. Stewart Catherine A. Stassen Frans L.	RU2733405C2
PHOSPHOINDOLES AS HIV INHIBITORS	2005	Storer Richard Dusson Siril Aleksandr Fransua-Rene Rolan Arlen	RU2393163C2
COMPLEXES	2015	Jon Deangelis, Andrew Colacot, Thomas	RU2684934C2
PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS	2001	Dehvis Robert Bebbington Dehvid Negtel Ronal'D Vehnnamehjker Marion Li Pehn Forester Kornelija Pirs Ehlbert Kehj Dehvid	RU2340611C2
COMPLEXES	2015	Colacot, Thomas Chow, Ruishan Jon Deangelis, Andrew	RU2682680C2
SUBSTITUTED N-(INDOLE-2-CARBONYL)-BETA-ALANYLAMIDES AND THEIR DERIVATIVES, METHOD OF TREATING GLYCOGENPHOSPHORYLAZO-DEPENDENT DISEASES, METHOD FOR PREVENTING ISCHEMIC MYOCARDIUM DAMAGES, AND PHARMACEUTICAL COMPOSITIONS	1996	Bernard Kh'Julin Judit Li Tredvej Vill'Jam Kholt Martin Dennis Dzhej Khuver	RU2159613C2
OBESITY TREATMENT	2019	Li, Chian Dzh. Derdak, Zoltan Stevanovich, Darko Lyu, Tszifen	RU2822679C2
TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE	2019	Li, Chian Dzh. Derdak, Zoltan Lyu, Tszifen	RU2815647C2

RU 2 448 087 C2

Authors

Toskano Dzhon P.

Brukfild Frederik Artur

Koehn Ehndrju D.

Kortni Stefen Martin

Frost Liza Mari

Kalish Vinsent Dzhejkob

Dates

2012-04-20—Published

2007-03-16—Filed