FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 4-(2,3-dimethylbenzyl)-1H-imidazole, also known as detomidine, having formula I: 
, which involves alkylation of trimethylsilyl imidazole with a compound of formula II: 
, where X: CI, Br, OH, in the presence of titanium tetrachloride in the medium of a chlorine-containing organic solvent, where molar ratio of titanium tetrachloride to N-trimethylsilyl imidazole must be maximum but must not be more than 0.95.
EFFECT: novel method of producing detomidine, characterised by high output of the end product.
1 cl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IMPROVED METHOD OF PRODUCING MEDETOMIDINE OR NON-TOXIC PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | 2010 |
|
RU2448094C1 |
| METHOD FOR PREPARING SUBSTITUTED IMIDAZOPYRIDINE | 2001 |
|
RU2275372C2 |
| METHOD OF SYNTHESIS OF N,N-DISUBSTITUTED AMINOMETHYLSTYRENES OR ALPHA-AMINOMETHYLSTYRENES | 2014 |
|
RU2673231C1 |
| METHOD OF PRODUCING LOSARTAN | 2006 |
|
RU2412940C2 |
| DERIVATIVES OF IMIDAZO[1,2-A]PYRIDINE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL PREPARATION BASED ON THEREOF, METHOD OF INHIBITION OF GASTRIC ACID SECRETION, METHOD OF TREATMENT OF GASTROENTERIC INFLAMMATORY DISEASES AND METHOD OF TREATMENT OF STATES WITH HELICOBACTER PYLORI INFECTION | 1998 |
|
RU2193036C2 |
| SUBSTITUTED EMIDAZOLES, METHODS OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON, AND METHOD OF MEDICAL TREATMENT | 1992 |
|
RU2120440C1 |
| DIALKYL(ARYL)-CIS-2-(2-HYDROXYARYL)-2-ALKYL(ARYL)ETHENYLPHOSPHINE OXIDES AND METHOD OF OBTAINING THEM | 2007 |
|
RU2329271C1 |
| METHOD OF RECYCLING ORGANOCHLORIDE WASTES FROM EPICHLOROHYDRIN PRODUCTION (VERSIONS) | 2008 |
|
RU2374276C1 |
| METHOD OF OBTAINING POLY-ALPHA-OLEFINS AND COPOLYMERS OF ALPHA-OLEFINS WITH DIENES WITH APPLICATION OF INITIATING SYSTEM BASED ON IONIC LIQUIDS | 2012 |
|
RU2542581C2 |
| METHOD OF PRODUCING AMIDE COMPOUND | 2008 |
|
RU2451681C2 |
