METHOD OF PRODUCING LOSARTAN Russian patent published in 2011 - IPC C07D403/10 

Abstract RU 2412940 C2

FIELD: chemistry.

SUBSTANCE: described is a method of producing a compound of general formula I where R1 denotes a radical of formula II: where R2 is a protective tetrazole group which is a novel intermediate compound when producing losartan - 2-n-butyl-4-chloro-5-hydroxymethyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4]methyl}-imidazole, and a method of producing losartan based on compound I by reducing the formyl group and then adding a chlorine atom to the imidazole ring and removing the protective R2 group.

EFFECT: method ensures high output of the end product from available starting and intermediate compounds on an industrial scale.

9 cl

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RU 2 412 940 C2

Authors

Vang Japing

Li Jongang

Li Julin

Zheng Guodzhun

Li Ji

Dates

2011-02-27Published

2006-02-02Filed