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2 448 094

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(51)

IPC

C07D233/56(2006-01-01)

(21) (22)

Application

2010150298/04, 2010-12-09

(24)

Start date

2010-12-09

(22)

Actual filing date

2010-12-09

(45)

Published

2012-04-20

(72)

Inventor

Eremin Oleg Gennad'EvichPoljakov Viktor StanislavovichBalaev Aleksandr NikolaevichZhidkov Mikhail Evgen'EvichKirillov Georgij Anatol'Evich

(73)

Holder

Eremin Oleg Gennad'EvichPoljakov Viktor Stanislavovich

IMPROVED METHOD OF PRODUCING MEDETOMIDINE OR NON-TOXIC PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Russian patent published in 2012 - IPC C07D233/56

Abstract RU 2448094 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to organic chemistry and specifically to a method of producing 4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, also known as medetomidine, having structural formula I: , which involves alkylation of N-trimethylsilyl imidazole with 2,3-trimethylbenzyl chloride in the presence of titanium tetrachloride in the medium of chlorine-containing organic solvents with molar ratio with 2,3-trimethylbenzyl chloride: trimethylsilyl imidazole:TiCl₄ equal to 1.0:4.0-5.0:3.6-4.5.

EFFECT: improved method of producing medetomidine, characterised by high output of the end product.

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RU 2 448 094 C1

Authors

Eremin Oleg Gennad'Evich

Poljakov Viktor Stanislavovich

Balaev Aleksandr Nikolaevich

Zhidkov Mikhail Evgen'Evich

Kirillov Georgij Anatol'Evich

Dates

2012-04-20—Published

2010-12-09—Filed