METHOD OF PRODUCING RAPAMYCIN DERIVATIVES Russian patent published in 2012 - IPC C07D498/18 

Abstract RU 2448970 C2

FIELD: chemistry.

SUBSTANCE: present invention describes methods of producing 32-deoxorapamycin from 32-iodo- or 32-hydroxyrapamycin, in which the hydroxy group is substituted with an arylthiocarbonate or an arylthiocarbamate residue, in the presence of tris(trimethylsilyl)silane and α,α'-azoisobutyronitrile in an organic solvent.

EFFECT: efficient method of producing said compounds.

5 cl, 4 dwg, 2 ex

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RU 2 448 970 C2

Authors

Atsemogly Murat

Pfeffer Zabine

Dates

2012-04-27Published

2007-01-22Filed