FIELD: chemistry.
SUBSTANCE: present invention describes methods of producing 32-deoxorapamycin from 32-iodo- or 32-hydroxyrapamycin, in which the hydroxy group is substituted with an arylthiocarbonate or an arylthiocarbamate residue, in the presence of tris(trimethylsilyl)silane and α,α'-azoisobutyronitrile in an organic solvent.
EFFECT: efficient method of producing said compounds.
5 cl, 4 dwg, 2 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PRODUCING MACROCYCLIC COMPOUNDS | 2006 |
|
RU2456296C2 |
DERIVATIVES OF OXADIAZOLE | 1997 |
|
RU2182905C2 |
METHOD FOR PREPARING BIARYL-SUBSTITUTED 4-AMINOBUTYRIC ACID OR ITS DERIVATIVES AND USE THEREOF IN PREPARING NEP INHIBITORS | 2007 |
|
RU2469019C2 |
β--LACTAM OR ITS ENANTIOMER FOR SYNTHESIS OF TAXOLS AND A METHOD OF TAXOL SYNTHESIS | 1990 |
|
RU2097374C1 |
AMINOALKYLAMIDOMETHYL-SUBSTITUTED DERIVATIVES OF 2-(4-SULFONYLAMINO)-3-HYDROXY-3,4-DIHYDRO-2H-CHROMAN-6-YL AND MEDICATIONS, CONTAINING SAID COMPOUNDS | 2006 |
|
RU2413725C2 |
PIRAZOLOIMIDAZOPYRIMIDINE DERIVATIVES WITH ANTAGONIST ACTIVITY TO CORTICOTROPHIN RELEASE FACTOR (CRF) | 2004 |
|
RU2377241C2 |
MIF INHIBITORS | 2005 |
|
RU2383541C2 |
OBTAINING DIHYDROTHIENO[3,2-d]PYRIMIDINES AND INTERMEDIATE PRODUCTS, APPLIED FOR THEIR SYNTHESIS | 2008 |
|
RU2528340C2 |
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2678305C1 |
TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2696270C1 |
Authors
Dates
2012-04-27—Published
2007-01-22—Filed