Show metadata Hide metadata

(19)

(11)

2 696 270

(13)

(51)

IPC

C07D471/04(2006-01-01)

A61K31/437(2006-01-01)

A61P3/00(2006-01-01)

A61P9/00(2006-01-01)

A61P25/28(2006-01-01)

A61P27/00(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2016127437, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-08-01

(72)

Inventor

Defej SabineKher Yag PaulDzhekson Viktoriya ElizabetDzhonson Dzhejms EndryuKroplin BorisPorter Dzhon Robert

(73)

Holder

Ucb Biopharma Sprl

TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D471/04 A61K31/437 A61P3/00 A61P9/00 A61P25/28 A61P27/00 A61P29/00 A61P35/00 A61P37/00

Abstract RU 2696270 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivative of formula (IIA) or a pharmaceutically acceptable salt thereof, where E denotes -CH₂-; Q is -CH₂O-; Z is (oxo)oxazolidinylphenyl; R¹¹ denotes hydrogen; R¹² is hydrogen or halogen; R¹⁵ denotes a difluoromethoxy group; and R¹⁶ denotes hydrogen. Invention also relates to a pharmaceutical composition based on a compound of formula (IIA), use thereof and a method of treating and/or preventing rheumatoid arthritis or Crohn's disease.

EFFECT: obtaining novel heterocyclic compounds having the properties of a TNFα activity modulator.

6 cl, 4 ex

Similar patents RU2696270C1

Title	Year	Author	Number
TRIAZOLOPYRIDAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer	RU2677698C1
IMIDAZOTHIAZOLE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Aleksander Rikki Piter Ali Mezkher Khussejn Braun Dzhulien Alister Dzhekson Viktoriya Elizabet	RU2683940C1
BENZOTRIAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Kroplin Boris	RU2677696C1
IMIDAZOPYRIMIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Ali Mezkher Khussejn Brukings Daniel Kristofer Braun Dzhulien Alister Dzhekson Viktoriya Elizabet Kroplin Boris Porter Dzhon Robert	RU2691629C1
TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Dzhekson Viktoriya Elizabet Kroplin Boris Loue Martin Aleksander Porter Dzhon Robert	RU2684635C1
PYRAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Dzhekson Viktoriya Elizabet Kroplin Boris	RU2684641C1
TRIAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Dzhekson Viktoriya Elizabet	RU2677697C1
IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Ali Mezkher Khussejn Brukings Daniel Kristofer Braun Dzhulien Alister Khatchings Martin Klajv Dzhekson Viktoriya Elizabet Kroplin Boris Porter Dzhon Robert Kuinsi Dzhoanna Rejchel	RU2679609C1
CONDENSED BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Aleksander Rikki Piter Foulks Gregori Khatchings Martin Klajv Dzhekson Viktoriya Elizabet Kroplin Boris Ryuberson Dzhejms Tomas Ruk Sera Margaret Chzhu Chzhoanin	RU2685234C1
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Delini Mikhael Lui Rober Kher Yag Paul Dzhekson Viktoriya Elizabet Kroplin Boris Lekomt Faben Klod Porter Dzhon Robert	RU2678305C1

RU 2 696 270 C1

Authors

Defej Sabine

Kher Yag Paul

Dzhekson Viktoriya Elizabet

Dzhonson Dzhejms Endryu

Kroplin Boris

Porter Dzhon Robert

Dates

2019-08-01—Published

2014-12-08—Filed