β--LACTAM OR ITS ENANTIOMER FOR SYNTHESIS OF TAXOLS AND A METHOD OF TAXOL SYNTHESIS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to β--lactam of the formula (III): β- or its enantiomer where means R₁-alkyl, C₁-C₆-- or α--naphthyl or unsubstituted phenyl or phenyl substituted with β--alkoxy-group; C₁-C₆ means hydroxy-protective group, for example, ethoxyethyl; R₂ means R₃-alkyl, C₁-C₆-- or α--naphthyl or unsubstituted phenyl or phenyl substituted with β--alkoxy-group. Method involves interaction of the indicated C₁-C₆-lactam and alcohol in the presence of an activating agent, synthesis of an intermediate taxol compound followed by its conversion to taxol. Method is used for synthesis both natural taxols and synthetic taxols. Taxols show anticancer effect at broad spectrum of antileukemic and tumor-inhibiting activity. EFFECT: improved method of synthesis. 12 cl