METHOD OF DIAGNOSING DISORDER OF MINERAL METABOLISM IN ORAL CAVITY AND PREDISPOSITION TO TEETH CARIES Russian patent published in 2012 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: by biochemical analysis of mixed non-stimulated saliva content of calcium and phosphorus compounds and activity of alkaline phosphatase are determined. Diagnosed are: reduction of saliva remineralising ability at A_ap lower than 0.1, where A_ap is alkaline phosphatase activity, mckat/l. Calcium deficiency if calcium content (K_Ca) is lower than limit value L_Ca (mmol/l), determined depending on alkaline phosphatase activity and phosphorus concentration (C_p mmol/l), if A_ap is lower than or equals 1.0, L_Ca equals 0.5; if A_ap is higher than 1.0, L_Ca is determined by formula: L_Ca=0.43+0.7 A_ap, if phosphorus concentration C_p (mmol/l) is more than 10 to limit value L_Ca added is deduction, determined by formula: 0.05 C_p - 10. Phosphorus deficiency in case of phosphorus content lower than limit value L_P (mmol/l), determined depending on alkaline phosphatase activity, if A_ap is lower than or equals 1.0, L_P=2.5, if A_ap is higher than 1.0, L_p is determined by formula: L_p=1.7+0.8 A_ap.

EFFECT: increased accuracy of diagnosing disorder of mineral metabolism in oral cavity by means of non-invasive method of analysis.

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