FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely to therapy, and may be used for treating the disorders related to CXCL13 activity in an animal's cell, tissue, organ or body wherein the disorders represent chronic obstructive pulmonary disease (COPD) or systemic lupus erythematosus. That is ensured by introducing a CXCL13 antagonist into the animal's cell, tissue, organ or body in an amount effective for CXCL13 activity inhibition together with a TNFα antagonist in an amount effective for TNFα activity inhibition in said animal's cell, tissue, organ or body.
EFFECT: group of inventions provides treating chronic obstructive pulmonary disease and systemic lupus erythematosus due to the combined use of the CXCL13 and TNFα specific monoclonal antibodies that leads to decreased CD4 expressing B-cell infiltration, and also reduced glomerulonephritis related urinary protein in an animal with symptoms of systemic lupus erythematosus.
19 cl, 8 dwg, 3 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| LIGAND GITR AND MOLECULES AND ANTIBODIES BOUND WITH LIGAND GITR, AND VERSIONS OF THEIR APPLICATION | 2004 |
|
RU2369636C2 |
| ANTAGONISTS AND METHOD OF USING SAID ANTAGONISTS | 2005 |
|
RU2401842C2 |
| HETERODIMERIC POLIPEPTIDES IL-17 A/F AND POSSIBILITIES OF THEIR THERAPEUTIC APPLICATION | 2007 |
|
RU2440134C2 |
| NEW ISOFORMS OF VASCULAR ENDOTHELIAL CELL GROWTH INHIBITOR | 2002 |
|
RU2316591C2 |
| TREATMENT OF AUTOIMMUNE DISEASES IN PATIENT SUFFERING FROM INADEQUATE RESPONSE TO TNF-ALPHA INHIBITOR | 2004 |
|
RU2358762C9 |
| USING ANTIBODIES FOR TREATING AUTOIMMUNE DISEASES IN PATIENT WITH INADEQUATE RESPONSE TO TNF-ALPHA INHIBITOR | 2008 |
|
RU2489166C2 |
| HUMANIZED IMMUNE BODIES FOR CXCR5, THEIR SECONDARIES, AND THEIR USE | 2008 |
|
RU2571515C2 |
| RECOVERED HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT (VERSIONS), METHOD OF TREATING hTNFα-MEDIATED DISEASES WITH MEDIATION THEREOF (VERSIONS), PHARMACEUTICAL COMPOSITION, RECOMBINANT HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT, RECOVERED NUCLEIC ACID (VERSIONS) | 2005 |
|
RU2458704C9 |
| CHIMERIC PROTEIN COMPOSED OF NGF ANTAGONIST DOMAIN AND TNFα ANTAGONIST DOMAIN | 2015 |
|
RU2678810C2 |
| COMPOSITIONS AND METHODS FOR REGULATION OF VESSELS DEVELOPMENT | 2005 |
|
RU2365382C2 |
