CHIMERIC PROTEIN COMPOSED OF NGF ANTAGONIST DOMAIN AND TNFα ANTAGONIST DOMAIN Russian patent published in 2019 - IPC C07K16/22 C07K14/48 A61K39/00 

Abstract RU 2678810 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology and is a binding molecule that contains the NGF antagonist domain (nerve growth factor) and the TNFα antagonist domain (α-tumor necrosis factor), where the NGF antagonist is an antibody to NGF or its antigen-binding fragment, and where the TNFα antagonist domain contains a soluble TNFα-binding fragment of TNFR; where the antibody to NGF or its fragment contains the variable domain of the heavy chain (VH domain), containing a set of hypervariable sites (CDR) HCDR1, HCDR2, HCDR3, and a light chain variable domain (VL domain) containing a set of CDRs LCDR1, LCDR2 and LCDR3, moreover, HCDR1 has an amino acid sequence SEQ ID NO: 4, HCDR2 has an amino acid sequence SEQ ID NO: 5, HCDR3 has the amino acid sequence of any of SEQ ID NO: 6, 11 or 12, LCDR1 has an amino acid sequence SEQ ID NO: 8, LCDR2 has an amino acid sequence SEQ ID NO: 9, and LCDR3 has an amino acid sequence SEQ ID NO: 10; where is the TNFα antagonist domain contains an amino acid sequence that is at least 80 % identical to the sequence of SEQ ID NO: 13, or its functional fragment; and where this binding molecule is capable of binding NGF and TNFα. Also the invention relates to an analgesic composition comprising a binding molecule and a carrier.

EFFECT: administration of NGF antagonist and TNFα antagonist, proposed in this invention can control pain in a subject more effectively than administering an equivalent amount of NGF antagonist or TNFα antagonist in the form of monotherapy.

32 cl, 17 dwg, 1 tbl, 8 ex

Similar patents RU2678810C2

Title Year Author Number
CHIMERIC PROTEIN COMPOSED OF AN NGF ANTAGONIST DOMAIN AND A TNFΑ ANTAGONIST DOMAIN 2015
  • Schofield Darren
  • Sleeman Matthew Alexander
  • Chessell Iain Patrick
  • Hatcher Jonathan
  • Lowe David
RU2788122C2
ANTAGONISTS AND METHOD OF USING SAID ANTAGONISTS 2005
  • Brjuis Nil D.
  • Vulven Bendzhamin P.
  • Kholms Stiv
  • Tomlinson Ajan M.
  • Li Dzhennifer
  • Ehnever Karolin
  • Basran Amrik
  • Dzhouns Kejt
  • Vildt Ruud De
  • Blejn Stanislas Charlz
RU2401842C2
PARTNERS OF SPECIFIC BINDING WITH NGF 2006
  • Frehnks Rut
  • Bukanan Ehndrju Grajer
  • Tom Albert Dzhordzh
  • Uehlsh Frejzer Ehving
  • Blehnd-Uord Filip Ehntoni
  • Sliman Mehtt'Ju Aleksander
  • Mehtt'Juz Karl Ehntoni
  • Khart Silija Patrisija
  • Khokinson Dzhon
RU2406728C2
RECOVERED HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT (VERSIONS), METHOD OF TREATING hTNFα-MEDIATED DISEASES WITH MEDIATION THEREOF (VERSIONS), PHARMACEUTICAL COMPOSITION, RECOMBINANT HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT, RECOVERED NUCLEIC ACID (VERSIONS) 2005
  • Allen Debora Dzh.
  • Vogen Tristan Dzh.
  • Kajmaksalan Zera
  • Labkovski Boris
  • Makginess Brajen T.
  • Mankovich Dzhon Eh.
  • Roberts Ehndrju Dzh.
  • Sakorafash Pol'
  • Sehlfeld Dzhokhen G.
  • Uajt Majkl
  • Uilton Ehlison Dzh.
  • Khugenbum Khendrikus R. Dzh. M.
  • Shoehnkhaut Dehvid
RU2458704C9
UNIVERSAL TRANSMITTER MODULES THROUGH THE HEMATOENCEPHALITIC BARRIER 2014
  • Rueger, Petra
  • Tiefenthaler, Georg
  • Moessner, Ekkehard
  • Niewoehner, Jens
  • Hugenmatter, Adrian
  • Shao, Cuiying
  • Ros, Francesca
  • Xu, Gang
RU2799436C1
MONOVALENT CARRIER MODULES ACROSS BLOOD-BRAIN BARRIER 2014
  • Ryuger Petra
  • Tifentaler Georg
  • Messner Ekkekhard
  • Nivener Ens
  • Khugenmatter Andrian
  • Shao Tsujin
  • Ros Francheska
  • Syuj Gan
RU2694659C2
ANTIBODIES AGAINST NERVE GROWTH FACTOR AND METHODS FOR THEIR PRODUCTION AND APPLICATION 2012
  • Giring Devid
RU2644235C2
IL-6 ANTAGONISTS AND USES THEREOF 2013
  • Shmidt Majkl M.
  • Erbe Devid V.
  • Barns Tomas M.
  • Ferfajn Erik Stiven
  • Tisdejl Elison
RU2670943C9
ANTIBODIES AGAINST NERVE GROWTH FACTOR AND METHODS FOR THEIR PRODUCTION AND APPLICATION 2012
  • Gearing David
RU2640252C2
METHODS OF OSTEOARTHRITIS PAIN MANAGEMENT BY ADMINISTRATION OF NERVE GROWTH FACTOR ANTAGONIST AND COMPOSITIONS CONTAINING IT 2006
  • Rozental' Arnon
  • Shelton Dehvid L.
  • Uolik Patritsija Ehnn
RU2429013C2

RU 2 678 810 C2

Authors

Shofild Daren

Sliman Mettyu Aleksander

Chessell Ien Patrik

Khatcher Dzhonatan

Lou Devid

Dates

2019-02-01Published

2015-02-02Filed