AZAADAMANTANE DERIVATIVES AND METHODS FOR APPLYING Russian patent published in 2012 - IPC C07D451/14 C07D471/18 A61K31/439 A61K31/444 A61K31/496 A61K31/497 A61K31/501 A61K31/506 A61P25/00 A61P25/04 A61P25/14 A61P25/18 A61P25/28 A61P25/34 A61P3/10 A61P15/08 A61P17/02 A61P19/02 A61P9/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to azaadamantane derivatives of formula (I), to their pharmaceutically acceptable salts possessing the properties of nAChR ligands, their application, a method of treating and based pharmaceutical compositions, and also to intermediate compounds of formula (VI) and (VII) and to application of the compound of formula (V) for preparing the compound (I). In general formulas

L₁ represents -O- or -NR_a-; A represents -Ar₁ or -Ar₂-L₂- Ar₃; Ar₁ represents 5-9-member heteroaryl wherein said heteroaryl is optionally substituted by alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, carboxy, carboxyalkyl, cyano, halogenalkoxy, halogenalkyl, halogen, hydroxy, nitro, -NH₂, (NH₂)carbonyl and oxido; Ar₂ represents 5-6-member heteroaryl wherein said heteroaryl is optionally substituted by alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, carboxy, carboxy alkyl, cyano, halogenalkoxy, halogenalkyl, halogen, hydroxy, nitro, -NH₂ and (NH₂) carbonyl; Ar₃ represents aryl, optionally substituted alkoxy, alkoxyhalogenalkyl, alkyl, aryl, halogenalkoxy, halogen, hydroxy and -NH₂; or Ar₃ 5-9-member heteroaryl wherein said heteroaryl is optionally substituted by alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, aryl, carboxy, carboxyalkyl, halogenalkyl, heterocyclyl and tritylaryl; L₂ represents a bond, -O- or -C(O)NR_a-; and R_a represents hydrogen.

EFFECT: preparing the pharmaceutically acceptable salts possessing the properties of nAChR ligands.

41 cl, 11 dwg, 162 ex