DERIVATIVES OF AZA-ADAMANTANES AND THEIR APPLICATION Russian patent published in 2018 - IPC C07D471/08 A61K31/439 A61K31/404 A61K31/4184 A61K31/428 A61P3/06 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I)

,

where: each R¹, R^1a and R² is independently selected from the group consisting of H, halogen, OH, CN, CF₃, OCF₃, OCH₃, CH₂OH, C₃cycloalkyloxy, COOH, CONR³R⁴ and tetrazole; Ar is a group of the following formula:

,

e is an integer selected from the group consisting of 0, 1, 2, 3 and 4; f e is an integer selected from the group consisting of 0, 1, 2 and 3; where each R⁸ is independently selected from the group consisting of H, halogen, methoxy, OCF₃, OCF₂H, isopropoxy, methyl, propyl, 4-fluorophenyl, thiophene, furan, 5-fluorofuran, 5-fluorothiophene, 5-chlorothiophene, 5-chlorofuran, OSO₂CF₃, OSO₂CH₃, cyclopropyl and cyclopropyloxy; where R⁹ is selected from the group consisting of H and methyl; A is -CR^aR^b-; B represents a group of the formula -(CR^cR^d)_n-; where each R^a and R^b is independently selected from the group consisting of H, methyl, ethyl, isopropyl, cyclopropyl, phenyl, 4-chlorophenyl, 4-fluorophenyl and thiophen-2-yl; where R^c and R^b are both H; where each R³ and R⁴ is H, n is an integer selected from the group consisting of 0 and 1; a is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10.

EFFECT: compounds that are capable of inhibiting 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are useful in the treatment of conditions such as non-insulin-dependent diabetes mellitus type 2 (NIDDM), insulin resistance, obesity, dyslipidemia.

20 cl, 1 tbl, 238 ex