FIELD: chemistry.
SUBSTANCE: present invention relates to new compounds of formulae and , in which radicals and symbols assume values defined in the formula of invention, e.g. to 1H-indazoles, 1,2-benzisoxazoles and 1,2-benzisothiazoles. Said compounds are receptor ligands of the α-7 nAChR subtype. The invention also relates to a pharmaceutical composition containing the said compounds.
EFFECT: possibility of using the said compounds to make medicinal agents for treating diseases associated with impaired functioning of nicotinic acetylcholine receptors and their abnormal functioning, primarily in brain cells.
46 cl, 85 ex
Title | Year | Author | Number |
---|---|---|---|
INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZOISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, PREPARING AND USING THEM | 2006 |
|
RU2450003C2 |
DERIVANTS OF BICYCLO[2, 2, 1] HEPT-7-YLAMINE AND THEIR APPLICATIONS | 2006 |
|
RU2442771C2 |
LIGANDS OF NICOTINE RECEPTOR α, THEIR OBTAINING AND APPLICATION | 2005 |
|
RU2418797C2 |
3-CARBOXALDEHYDE DERIVATIVES OF QUINOLINE | 1995 |
|
RU2097379C1 |
NOVEL CYCLOPENTANE DERIVATIVES | 2010 |
|
RU2572555C2 |
2-OXA-5-AZABICYCLO[2.2.1]HEPTANE-3-YL DERIVATIVES | 2015 |
|
RU2697651C2 |
CONDENSED QUINOLINE DERIVATIVE AND USE THEREOF | 2005 |
|
RU2384571C2 |
METHOD OF PRODUCING SUBSTITUTED DIAZOBYCYCLOALKYLOQUINOLONE CARBOLIC ACIDS WITH BRIDGE BONDS OR THEIR PHARMACEUTICALLY ACCEPTABLE ADDITIVE SALTS | 0 |
|
SU1482531A3 |
SUBSTITUTED DIAMINO-CARBOXAMIDE AND DIAMINO-CARBONITRILE PYRIMIDINE DERIVATIVES, THEIR COMPOSITIONS AND METHODS OF TREATMENT USING THEM | 2012 |
|
RU2625309C2 |
2-AMINOBENZOTHIAZOLYLUREAS AS ADENOSINE MODULATORS | 2002 |
|
RU2311905C2 |
Authors
Dates
2010-05-20—Published
2004-12-22—Filed