1H-INDAZOLES, 1,2-BENZISOXAZOLES AND 1,2-BENZISOTHIAZOLES, SYNTHESIS THEREOF AND USE Russian patent published in 2010 - IPC C07D471/06 C07D487/08 A61K31/439 A61K31/407 A61K31/416 A61K31/423 A61K31/428 A61P25/00 A61P25/28 

Abstract RU 2389729 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to new compounds of formulae and , in which radicals and symbols assume values defined in the formula of invention, e.g. to 1H-indazoles, 1,2-benzisoxazoles and 1,2-benzisothiazoles. Said compounds are receptor ligands of the α-7 nAChR subtype. The invention also relates to a pharmaceutical composition containing the said compounds.

EFFECT: possibility of using the said compounds to make medicinal agents for treating diseases associated with impaired functioning of nicotinic acetylcholine receptors and their abnormal functioning, primarily in brain cells.

46 cl, 85 ex

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RU 2 389 729 C2

Authors

Se Vehn'Ge

Kherbert Brajan

Ma Jan'Guo

Ngujen Truk Min

Shumakher Richard A.

Goss Karla-Marija

Tekhim Ashok

Dates

2010-05-20Published

2004-12-22Filed