LIGANDS OF NICOTINE RECEPTOR α, THEIR OBTAINING AND APPLICATION Russian patent published in 2011 - IPC C07D453/02 A61K31/439 A61P25/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compound of formula I where X¹-X⁴ each independently represent CR¹, B represents -C(O)-O- or -C(O)-NH-CH₂-, Y represents S or NH, R¹ represents H, C₁-C₄alkoxy, unsubstituted or substituted by once or several times with F, or Het, and Het stands for heterocyclic group, fully saturated, partly saturated or fully unsaturated, containing in cycle 5-10 atoms, of which at least one atom represents N, O or S, unsubstituted or substituted once or several times with C₁-C₈alkyl, or to its pharmaceutically acceptable salt.

EFFECT: obtaining pharmaceutical composition for selective activation/stimulation of nicotine receptors α7 on the basis of said compound, as well as to their application for treatment of patient, suffering from psychotic disease, neurodegenerative disease, including cholinergic system dysfunction and/or condition of memory failure and/or failure of cognitive abilities.

52 cl, 38 ex