METHOD OF PRODUCING 4-DEMETHYLDAUNORUBICIN Russian patent published in 2012 - IPC C07H15/24 A61K31/704 A61P35/00

Abstract RU 2450013 C2

FIELD: chemistry.

SUBSTANCE: invention refers to method of producing anthracycline carminomycine of formula from anthracycline daunorubicin. Method involves reaction of daunorubicin of formula , or N-substituted daunorubicin of formula , where Prot=acyl, acyl halide, carbonate with a weak Lewis acid selected from a group comprising TiHal₄, BHal₃, MgHal₂, where Hal=F, Cl, Br, I, for demethylation of the 4-methyoxy group in daunorubicin of formula 2, or N-substituted daunorubicin of formula 3.

EFFECT: invention enables to obtain carminomycine using a method which does not lead to destruction of the C-7 glycoside bond and with fewer number of synthesis steps.

6 cl, 1 ex

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RU 2 450 013 C2

Authors

Zabudkin Aleksandr

Matvienko Viktor

Matveev Aleksej

Itkin Aleksandr

Dates

2012-05-10—Published

2006-12-13—Filed