METHOD OF TREATING DESTRUCTIVE PULMONARY TUBERCULOSIS Russian patent published in 2012 - IPC A61K38/00 A61P31/06 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely therapy of pulmonary tuberculosis. A method of treating pulmonary tuberculosis consists in introducing Bestim with underlying anti-tuberculosis preparations, and Bestim is introduced intratracheally in dose 1.0 mg 3 times a week; total therapeutic course makes 6 introductions. The preparation escaping a liver gets in the beginning to lungs and stays there for some time due to an ability of interstitial pulmonary tissue to keep medical substances quickly absorbed in pulmonary tissue. The efficacy of the integrated anti-tuberculosis treatment involving the intratracheal introduction of Bestim is increased: within the time limits to 2 months during an intensive phase of chemotherapy bacterioexcretion is terminated in 90.9 % vs. 50.1 % of control group (p<0.01) and the cavities are closed 50.0 % of patients vs. 27.0 % of control group. The main group shows 100% recovery of nonspecific endobronchitis. A cytokine imbalance is restored due to decreasing levels of proinflammatory cytokines (α -TNF (p <0.05) and γ-interferon), tends to increasing a level of anti-inflammatory cytokine IL-4.

EFFECT: method provides fast absorption of the preparation Bestim and delivery first of all into the lymphatic pulmonary system, then into the lesser circulation and only then into the greater circulation.