METHOD OF ESTIMATING LIVER FIBROSIS Russian patent published in 2012 - IPC A61B5/295 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, in particular hepatology. Polyhepatography is performed, amplitude, form of blood filling waves, basic body resistance in area of the liver and their change in carrying out two functional tests - with breath-holding and with nitroglycerin are measured. If wave amplitude is higher than 0.1 ohm, basic resistance is not higher than 100 ohm, wave shape looks "normal" or takes "normal" form in carrying out at least one of the two performed functional tests, absence of fibrosis is determined. If wave amplitude is higher than 0.1 ohm, basic resistance is not higher than 120 ohm, wave form looks normal "with plateau" at the beginning of systolic rise, which remains in functional test with nitroglycerin, liver fibrosis is estimated as periportal. If basic resistance is not higher than 140 ohm, wave has "two-phase asymmetric" form, does not tend to change to normal-looking form in functional test with nitroglycerin, liver fibrosis is estimated as portoportal. If basic resistance is not lower than 120 ohm, wave has "two-phase asymmetric" form with flattened diastola, with tendency to change towards normal-looking form in at least one of the two functional tests, liver fibrosis is estimated as portocentral. In case of amplitude not higher than 0.1 ohm, basic resistance higher than 150 ohm, wave has "two-phase asymmetric" form with flattened diastola, with no tendency to change towards normal-looking form in neither of the two functional tests, live cirrhosis is estimated. If basic resistance is higher than 100 ohm, wave has "plateau-like" form with no tendency to change towards normal-looking form in neither of the two functional tests, liver fibrosis is estimated as perivenular fibrosis. If wave has form "with local rise at the end of diastolic part, which does not tend to change towards normal-looking form in neither of the two functional tests, liver fibrosis is estimated as fibrosis of central pulmonary veins.

EFFECT: method makes it possible to carry out differential estimation of liver fibrosis at early stages of disease.

3 tbl, 8 dwg, 6 ex