FIELD: medicine.
SUBSTANCE: invention refers to a pharmaceutical composition effective for injections in the form of a water suspension for prolonged release of a bisphosphonate agent. Said pharmaceutical composition contains a combined dispersion complex containing a salt of a bisphosphonate agent and a salt of pentavalent phosphorus oxoacid, and the complex has solubility in physiologic saline less than 0.05 wt % at bisphosphonic acid. The invention also refers to a pharmaceutical composition effective for injection which contains the combined dispersion complex containing a calcium salt in the amount less than 50 wt %, a calcium salt of pentavalent phosphorus oxoacid with the solid substance having an average particle size 1-100 mcm, the calcium to phosphorus mass relation is equal to 0.5-3; and the composition has pH equal to 6-9.5 if the complex is suspended in an aqueous medium. The invention also refers to a method of treating or preventing of bone diseases in patients with, e.g. osteoporosis, implying the intramuscular introduction of said compositions in a patient's body.
EFFECT: invention aims at preparing the composition low soluble in the physiological medium and provides prolonged slow release of the bisphosphonate agents.
24 cl, 8 tbl, 3 dwg, 3 ex
