SOLID PHARMACEUTICAL COMPOSITION (VERSIONS) AND METHOD FOR CONTROLLING GLUCOSE CONCENTRATION THEREWITH, METHOD FOR PREPARING SOLID PHARMACEUTICAL COMPOSITIONS (VERSIONS), TABLET (VERSIONS) AND METHOD FOR MAKING AMORPHOUS PARTICLES Russian patent published in 2012 - IPC A61K38/28 A61K9/22 A61K47/12 A61K47/14 A61K47/48 A61J3/10 

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is presented is a solid oral pharmaceutical composition containing 0.01÷20 wt % IN-105, approximately 10÷60 wt % of saturated or unsaturated C₄-C₁₂ fatty acids, their esters and salts and at least one pharmaceutically acceptable excipient specified in a group containing at least 10 wt % of an aerating agent, 10 wt % of mannitol and 0.5 wt % of a lubricant. There are presented a method for controlling the blood glucose concentration with said composition, methods for preparing it and a tablet of weight 5÷500 mg. There are presented the solid pharmaceutical composition stable within the temperature range 2-40°C and different relative humidity values for at least 6 months and an insulinotropic pharmaceutical composition with three-time lower mitogenicity in comparison with a native analogue containing said composition. What is also presented is a method for making amorphous spray-dried particles.

EFFECT: invention provides preparing the oral pharmaceutical composition containing conjugated insulin of higher bioavailability and lower mitogenicity.

65 cl, 16 dwg, 16 tbl, 14 ex