METHOD FOR PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE FOLLOWING MARROW ALLOGRAFTING Russian patent published in 2012 - IPC A61K48/00 A61P37/06 

Abstract RU 2454247 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, more specifically to haematology, and is applicable for immune response modulation, particularly for prevention of acute graft-versus-host disease following marrow allografting. Donor multipotent mesenchymal stromal cells recovered from bone marrow, cultured on a human blood plasma medium enriched in platelet lysate are introduced intravenously in the amount of 1x106 grafted cells per one kg of patient's body weight at the moment of leukocyte recovery in patient's peripheral blood following marrow allografting min. 1.0×109/l.

EFFECT: method provides effective prevention of acute graft-versus-host disease following marrow allografting.

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RU 2 454 247 C1

Authors

Savchenko Valerij Grigor'Evich

Drize Nina Iosifovna

Kuz'Mina Larisa Anatol'Evna

Petinati Natal'Ja Arnol'Dovna

Parovichnikova Elena Nikolaevna

Shipunova Irina Nikolaevna

Svinareva Dar'Ja Anatol'Evna

Momotjuk Kira Sergeevna

Ol'Shanskaja Julija Vjacheslavovna

Dates

2012-06-27Published

2010-12-14Filed