FIELD: medicine, pharmaceutics.
SUBSTANCE: there are offered: using synergistically effective amounts of compounds of formula I (oridonin), II (particularly vogonin) and IV (particularly, 2,4,4'-trihydroxychalcone) for preparing a drug preparation for treating neoplasia resistant to a therapeutic agent, specified in a group consisting of prostate cancer, breast cancer, endometrial cancer, colon cancer, lung cancer, bladder cancer, testicular cancer, ovarian cancer, thyroid cancer and bone cancer; an appropriate composition and a method of treating. What is shown is: strong synergetic action of the ingredients of the composition according to the present invention. It makes them applicable in relatively low amounts to treating stage IV cancer or recurrent cancer which can be characterised by developed resistance to conventional chemotherapeutic agents.
EFFECT: compounds and methods according to the invention are especially applicable for treating human taxol-resistant cancers, particularly uterus neck cancer and breast cancer.
20 cl, 3 tbl
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