COMPOUNDS FOR TREATING CANCER Russian patent published in 2020 - IPC C07D403/04 C07D277/30 C07D417/12 A61K31/4184 A61K31/427 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: present invention relates to a compound of formula II, where Q is NH; Z is CH or N; A is phenyl, indolyl or indazolyl, each of which is optionally substituted with at least one of the following: C₁-C₅ linear or branched alkyl or a combination thereof; R₁ independently represents hydrogen, O-(C₁-C₅)alkyl, O-halogen(C₁-C₅)alkyl, halogen(C₁-C₅)alkyl, -O(CH₂)_jOCH₃, -O(CH₂)_jNHCH₃, -O(CH₂)_jNH₂, -O-(CH₂)_jN(CH₃)₂, - OC(O)CF₃, -OC(O)CH₂Cl, -OCH₂Ph, -O(CH₂)_jN-phthalimide or a combination thereof; R₂ is hydrogen, O-(C₁-C₅)alkyl, O-halogen(C₁-C₅)alkyl, F, Cl, Br, I, halogen(C₁-C₅)alkyl, CN, NO₂, -CH₂CN, NH₂, hydroxyl, COOH, C(O)H, NHCO-(C₁-C₅)alkyl, -O(CH₂)_kOCH₃, -O(CH₂)_kOH, -O(CH₂)_kNHCH₃, -O(CH₂)_kNH₂, -O-(CH₂)_kN(CH₃)₂, -OC(O)CF₃, -OC(O)CH₂Cl, -OCH₂Ph and -O(CH₂)_kN-phthalimide; j and k independently represent integers from 1 to 5; n is integer from 1 to 4; or a hydrate thereof, a pharmaceutically acceptable salt or a combination thereof.

EFFECT: compounds of formula II have anti-cancer activity and are intended for treating, relieving, reducing severity, reducing the risk of developing or suppressing cancer.

23 cl, 12 dwg, 4 tbl, 6 ex