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IPC

A61K35/32(2006-01-01)

B01D11/02(2006-01-01)

(21) (22)

Application

2011108938/15, 2011-03-10

(24)

Start date

2011-03-10

(22)

Actual filing date

2011-03-10

(45)

Published

2012-07-20

(72)

Inventor

Lunin Vladimir GlebovichKarjagina-Zhulina Anna StanislavovnaSharapova Natal'Ja Evgen'EvnaErshova Anna StepanovnaGromov Aleksandr ViktorovichNikitin Kirill Evgen'EvichSubbotina Marina Evgen'EvnaKotnova Alina PetrovnaLavrova Natal'Ja Vital'EvnaSemikhin Aleksandr SergeevichSoboleva Ljubov' AleksandrovnaGrunina Tat'Jana MikhajlovnaOvechkina Tat'Jana AndreevnaBartov Mikhail SergeevichMishina Dar'Ja MikhajlovnaGintsburg Aleksandr Leonidovich

(73)

Holder

Rossijskaja Federatsija, Ot Imeni Kotoroj Vystupaet Ministerstvo Promyshlennosti I Torgovli Rossijskoj Federatsii Rossii)Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Ehpidemiologii I Mikrobiologii Imeni Pochetnogo Akademika N.F. Gamalei" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii Im. N.F. Gamalei" Minzdravsotsrazvitija Rossii)

METHOD OF PRODUCING DEMINERALISED CRUSHED BONE MATRIX Russian patent published in 2012 - IPC A61K35/32 B01D11/02

Abstract RU 2456003 C1

FIELD: process engineering.

SUBSTANCE: invention relates to production of demineralised crushed bone matrix. Proposed method comprises bone crushing, bone fragments processing by Tween-80 solution, detergent removal and treatment by isopropanol-chloroform mix in ultrasound bath. Then, crumb is washed in water, processed by HCl solution , rinsed by distilled water and placed into phosphate buffer to be rinsed by distilled water. Obtained fragments are filled with ethanol. Crumb is dried, minced by mill and sized on vibratory screen to preset size, freeze-dried and sterilised at definite conditions.

EFFECT: high biocompatibility, osteoconductive and osteoinductive properties.

2 e

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RU 2 456 003 C1

Authors

Lunin Vladimir Glebovich

Karjagina-Zhulina Anna Stanislavovna

Sharapova Natal'Ja Evgen'Evna

Ershova Anna Stepanovna

Gromov Aleksandr Viktorovich

Nikitin Kirill Evgen'Evich

Subbotina Marina Evgen'Evna

Kotnova Alina Petrovna

Lavrova Natal'Ja Vital'Evna

Semikhin Aleksandr Sergeevich

Soboleva Ljubov' Aleksandrovna

Grunina Tat'Jana Mikhajlovna

Ovechkina Tat'Jana Andreevna

Bartov Mikhail Sergeevich

Mishina Dar'Ja Mikhajlovna

Gintsburg Aleksandr Leonidovich

Dates

2012-07-20—Published

2011-03-10—Filed