COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF HIV-PROTEASE ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) where Q₃ - aryl or S-aryl possibly substituted with halogen atom, aryl - a carbocyclic aromatic 5-14-membered monocyclic or polycyclic residue; A - a carbocyclic aromatic 5-14-membered monocyclic or polycyclic residue, pyridine, pyridine-N-oxidyl, quinoline, isoquinoline, indole, indoline, thiazole-1,1-dioxide, thiophene or thiophene-1,1-dioxide; B - a carbocyclic aromatic 5-14-membered monocyclic or polycyclic residue involving nitrogen heteroatom, pyridylmethylpiperazine, octahydrothieno[3,2-c]pyridine or octahydrothieno[3,2-c] pyridine-1,1-dioxide; Q₁,Q₂ mean independently hydrogen atom or alkyl; Q_4-8 mean independently hydrogen atom, hydroxyl, halogen atom, nitro-, amino-, sulfonylamino-, alkylamino-group, alkyl possibly substituted with halogen atom, alkoxyl, the group -O-J (where J is a hydrolyzable group) or the group L₆C(O)L₄ (where L₆ - a single bond or -O and L₄ - alkyl or alkoxyl); Y and G - oxygen atom; D - carbon or nitrogen atom being D atom is bound by a single bond with each of adjacent atoms of ring; E - carbon atom; Q₉ - hydrogen atom, or its pharmaceutically acceptable salt or a pharmaceutical composition based on said that inhibits activity of HIV-protease. EFFECT: compounds as inhibitors of HIV-protease. 63 cl, 3 tbl, 73 ex