FIELD: medicine, pharmaceutics.
SUBSTANCE: pressed solid pharmaceutical dosage form contains tadalafil and starch. The weight relation of starch to tadalafil makes approximately 5:1 or more. Tadalafil particle size distribution is such to ensure d(0.9) being 40 mcm or more. Hardness of the pressed solid dosage form makes 5 Strong Cobb Units or more. There are also described methods for preparing tadalafil tablets. The dosage form of tadalafil is applied for treating erectile dysfunction in males.
EFFECT: dosage form of erectile dysfunction under the invention having the greater particles shows high dissolution rate when approximately 60%, preferentially 68% or more of tadalafil is released for 20 minutes if taken in a dose of 20 mg of tadalafil.
94 cl, 1 dwg, 10 tbl, 9 ex
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