FIELD: medicine.
SUBSTANCE: described are compressed tablets for oral administration containing Raltegravir in form of pharmaceutically acceptable salt. Tablet contains: (A) intra-granular component containing (i) effective amount of Raltegravir potassium salt, (ii) first super-expander, and (iii) binding agent; and (B) extra-granular component containing (i) second super-expander, (ii) excipient, and (iii) lubricating agent. Super-expander represents sodium croscarmellose, excipient represents microcrystalline cellulose or combination of microcrystalline cellulose and dibasic calcium phosphate, lubricating agent is magnesium stearate. Tablet contains neither atazanavir nor its pharmaceutically acceptable salt.
EFFECT: compressed tablets according to invention are characterized by high load by medicinal substance at acceptable size tablet.
11 cl, 1 dwg, 3 ex
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