METHOD, COMPOUND AND PHARMACEUTICAL COMPOSITION AND DRUG FOR NORMAL AND PATHOLOGICAL MEMORY LOSS RECOVERY Russian patent published in 2012 - IPC C07D401/12 C07D401/14 C07D405/14 A61K31/4427 A61K31/4523 A61P25/28 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for recovery of memory loss caused by a pathology, adverse effects or with time that involves the introduction of an effective amount of (azaheterocyclyl)alkyl amide het(aryl)glycine derivatives of general formula I: wherein: m and n can have values 0, 1, 2 and 3; the sign (#) in what follows means the potential presence of a chiral centre; R represents optionally substituted C₅-C₁₀ aryl or 5-6-member hetaryl containing 1-2 heteroatoms specified in nitrogen and sulphur, optionally condensed with a benzene ring with substitutes specified in C₁-C₈alkyl, C₁-C₈alkoxy, halogen, OH, CF₃, CN, NO₂, CF₃O, an unsubstituted amino group or a monoC_1-6alkyl- or di(C_1-6alkyl) substituted amino group, C_1-8 alkylsulphanyl, C_1-8 alkoxycarbonyl, C₁-C₆acyl; A1 and A2 independently represents optionally substituted 5-6 member saturated, or aromatic azaheterocyclyl containing 1 to 2 nitrogen atoms in the cycle and optionally condensed with benzene ring; the substitutes in the substituted groups R, A1 and A2 are independently specified in C₁-C₈alkyl, C₁-C₈alkoxy, C₁-C₈ alkylsulphanyl, halogen, OH, CF₃, nitro, CN, CF₃O, an unsubstituted amino group, mono-C_1-4alkyl- or a di(C_1-4alkyl) amino group, C_1-8 alkoxycarbonyl, C₁-C₆acyl, or their pharmaceutically acceptable salts or alkyl esters in the form of isolated optical isomers, or their mixtures. The invention refers to the compounds of general formula I, the based pharmaceutical composition and drug.

EFFECT: recovery of memory loss caused by a pathology, adverse effects or with time.

16 cl, 24 ex, 1 tbl, 20 dwg