HETEROCYCLIC LOW-MOLECULAR sAPP-MIMETICS, PHARMACEUTICAL COMPOSITION, METHODS FOR PREPARING AND USING Russian patent published in 2012 - IPC C07D401/12 C07D401/14 C07D405/14 A61K31/4427 A61K31/4523 A61P25/28 

FIELD: medicine.

SUBSTANCE: invention refers to new heterocyclic compounds of formula I wherein: n and m may have values 0, 1, 2 and 3; the sign (#) in what follows means the potential presence of a chiral centre; R represents optionally substituted C₅-C₁₀aryl or 5-6-member hetaryl containing 1-2 heteroatoms specified in nitrogen, oxygen and sulphur optionally condensed with a benzene ring with the substitutes specified in C₁-C₈alkyl, C₁-C₈alkoxy, halogen, OH, CF₃, NO₂, CF₃O, COOH, an unsubstituted amino group or mono-C_1-6alkyl- or di(C_1-6alkyl)substituted amino-group, C_1-8alkylsulphanyl, C_1-8alkoxycarbonyl; A₁ and A₂ independently represent optionally substituted 5-6 member saturated, or aromatic azaheterocycle containing 1 to 2 nitrogen atoms in the cycle and optionally condensed with the benzene ring; or to their pharmaceutically acceptable salts or alkyl esters in the form of isolated optical isomers, or their mixtures. Also, the invention refers to a pharmaceutical composition on the basis of the compound of formula I, to a drug on the basis of the compound of formula I, as well as to a method for preparing the compound of formula I.

EFFECT: there are prepared new non-peptide heterocyclic low-molecular peptidomimetics of a secretory amyloid peptide precursor sAAP showing an ability to have an effective effect on the processes of formation, storage and restoration of the memory lost in health and none.

10 cl, 4 dwg, 22 ex